Description

Boc-Leu-Enkephalin is a protected peptide derivative of the endogenous opioid peptide, Leu-Enkephalin. This compound is a crucial intermediate in peptide synthesis, offering a strategic balance between stability during chemical manipulation and ease of deprotection. It is primarily utilized by research institutions and pharmaceutical developers in neuroscience, pharmacology, and medicinal chemistry. Its role is fundamental in studying opioid receptor interactions and developing novel therapeutic agents.

Application

• Neuroscience Research: As a key tool for investigating the structure-activity relationships (SAR) of enkephalins and their binding to delta (δ) and mu (μ) opioid receptors.
• Pharmaceutical Intermediate: Serves as a protected building block in the solid-phase or solution-phase synthesis of longer, more complex opioid peptides and peptide mimetics.
• Biochemical Assay Development: Used in the development of competitive binding assays and receptor characterization studies to screen for new analgesic compounds.
• Medicinal Chemistry: Acts as a precursor for the synthesis of labeled analogs (e.g., fluorescent, radioactive) for in vitro and in vivo imaging and tracing studies.
• Academic Research: Employed in university and institutional labs for fundamental studies on pain pathways, neurobiology, and peptide hormone function.

Basic Information

Product Name	Boc-Leu-Enkephalin
CAS No.	64963-27-5
Molecular Formula	C34H47N5O9
Molecular Weight	669.77 g/mol
Synonyms	Boc-Tyr-Gly-Gly-Phe-Leu-OH; N-tert-Butoxycarbonyl-Leu-Enkephalin; Boc-Leu-Enkephalin; Boc-L-Enkephalin; Boc-Leu-Enk; tert-Butyloxycarbonyl-Leucine Enkephalin; N-Boc-Leu-Enkephalin; Boc-Tyr-Gly-Gly-Phe-Leu
EINECS	Contact for details

Quality Control

Our Boc-Leu-Enkephalin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.