Description

Enkephalin-Leu, Ala(2)-Me-Phe(4)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, featuring specific amino acid modifications to enhance its stability and receptor binding profile. This compound is of significant interest for advanced research in neurobiology and pharmacology, particularly in the study of pain modulation and opioid receptor mechanisms. It serves as a critical tool for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on central nervous system (CNS) disorders and novel therapeutic discovery.

Application

• Neuroscience Research: As a potent and selective ligand for studying δ-opioid receptor (DOR) activity and signal transduction pathways.
• Pharmacological Assay Development: Used as a reference standard or active agent in high-throughput screening (HTS) for identifying new analgesics with reduced side-effect profiles.
• Biochemical Tool Compound: Employed in in vitro binding studies, autoradiography, and functional assays to elucidate the role of enkephalinergic systems.
• Drug Discovery & Preclinical Studies: A key intermediate or pharmacophore model for the design and synthesis of novel peptide-based therapeutics targeting chronic pain.
• Academic & Institutional Research: Fundamental research into the biochemistry of neuropeptides, their degradation, and their physiological effects.

Basic Information

Product Name	Enkephalin-Leu, Ala(2)-Me-Phe(4)-
CAS No.	64963-13-9
Molecular Formula	C34H48N6O7
Molecular Weight	652.8 g/mol
Synonyms	H-Tyr-D-Ala-Gly-Phe-Nle-OH; [D-Ala2, Nle5]-Enkephalin; DADLE-Nle; [D-Ala2, Leu5]-Enkephalin, Ala(2)-Me-Phe(4) derivative; Tyr-D-Ala-Gly-Phe-Leu-NH2 analog; δ-opioid receptor selective peptide; FK 33-824 related peptide
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, Ala(2)-Me-Phe(4)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.