Description

Enkephalin, Thr(2)-Thz(5)-Glynh2(3)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, incorporating the non-proteinogenic amino acid thiazolidine (Thz). This compound is of significant interest for its potential role in modulating opioid receptor activity and related neurological pathways. It serves as a critical research tool for neuroscientists and pharmaceutical developers investigating pain management, neuroprotection, and addiction mechanisms. The product is supplied under stringent quality controls to ensure batch-to-batch consistency for reliable experimental results.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate delta and mu opioid receptor subtypes.
• Pharmacological Development: Serves as a lead compound or reference standard in the discovery and development of novel analgesic and neuroprotective agents.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the impact of thiazolidine incorporation on peptide stability, bioavailability, and receptor affinity.
• Cell Signaling Pathways: A tool for exploring the role of enkephalinergic systems in cellular models of pain, inflammation, and neuroplasticity.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental research in neurochemistry and peptide biology.

Basic Information

Product Name	Enkephalin, Thr(2)-Thz(5)-Glynh2(3)-
CAS No.	64889-80-1
Molecular Formula	C28H40N8O9S
Molecular Weight	664.73 g/mol
Synonyms	[Thr2, Thz5]-Enkephalinamide; H-Tyr-Thr-Gly-Phe-Thz-NH2; (2S)-2-[[(2S)-2-[[2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenyl-N-[(4R)-1,3-thiazolidin-4-yl]propanamide; Thz5-Enkephalin; Thiazolidine-5-Enkephalin; Opioid Peptide Analog; δ-Selective Enkephalin Analog
EINECS	Contact for details

Quality Control

Our Enkephalin, Thr(2)-Thz(5)-Glynh2(3)- is manufactured under controlled conditions to ensure the highest standards of purity and identity. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity assessment, mass spectrometry (MS) for confirmation of molecular weight, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to GMP principles for research-grade peptides to guarantee reliability for your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.