Description

Enkephalin, Met(2)-Thz(5)-Glynh2(3)- CAS NO 64889-79-8 is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, featuring specific amino acid substitutions at positions 2 and 5, and a C-terminal amide modification. This engineered structure is critical for enhancing metabolic stability and receptor selectivity, making it a valuable tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and opioid receptor signaling pathways.

Application

• Neuroscience Research: As a selective ligand for studying delta and mu opioid receptor subtypes, their distribution, and downstream signaling cascades.
• Pharmacological Assay Development: Used as a reference standard or active control in high-throughput screening (HTS) for novel analgesic drug discovery.
• Structure-Activity Relationship (SAR) Studies: Serves as a key molecular scaffold to investigate the impact of specific amino acid modifications on peptide potency, stability, and binding affinity.
• Biochemical Research: Employed in enzyme interaction studies, particularly concerning peptidase degradation pathways and metabolic stability assays.
• Academic & Clinical Research: Supports fundamental research into the endogenous opioid system, its role in pain perception, addiction, and mood disorders.

Basic Information

Product Name	Enkephalin, Met(2)-Thz(5)-Glynh2(3)- CAS NO 64889-79-8
CAS No.	64889-79-8
Molecular Formula	C30H40N8O7S2
Molecular Weight	688.82 g/mol
Synonyms	[Met2, Thz5]-Enkephalinamide; H-Tyr-Gly-Gly-Phe-Met-NH2 (Thz analog); [2-Methionine, 5-Thiazolidine]-Enkephalin Amide; Modified Enkephalin Peptide; Opioid Receptor Peptide Ligand; [Met2,Thz5]Enk-NH2; Thiazolidine-containing Enkephalin; CAS 64889-79-8
EINECS	Contact for details

Quality Control

Our Enkephalin, Met(2)-Thz(5)-Glynh2(3)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure it meets the stringent requirements of research applications. Certificates of Analysis (COA) detailing purity, chromatographic data, and analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.