Description

H-3,4-Dehydro-Pro-Nh2 Hcl is a specialized amino acid derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive peptides. Industries that need it include pharmaceutical R&D, biotechnology, and fine chemical manufacturing for producing targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of peptidomimetics and constrained peptides for drug discovery programs.
• Bioconjugation Chemistry: Used to introduce specific functional handles or modify peptide backbones for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Proteomics Research: Serves as a non-natural amino acid analog in structural biology studies to investigate protein folding and function.
• Medicinal Chemistry: Employed in the design and synthesis of enzyme inhibitors and receptor modulators targeting various disease pathways.
• Chemical Biology Tool: Utilized for labeling or cross-linking applications in studying biomolecular interactions.

Basic Information

Product Name	H-3,4-Dehydro-Pro-Nh2 Hcl
CAS No.	64869-59-6
Molecular Formula	C5H9ClN2O
Molecular Weight	148.59 g/mol
Synonyms	3,4-Dehydroprolinamide hydrochloride; (2S)-3,4-Didehydroprolineamide hydrochloride; H-δ3,4-Pro-NH2·HCl; 3,4-Dehydro-L-prolinamide hydrochloride; 1-Pyrroline-2-carboxamide hydrochloride; δ3,4-Pro-NH2 HCl; L-3,4-Dehydroprolinamide HCl; 2-Carbamoyl-1-pyrroline hydrochloride
EINECS	Contact for details

Quality Control

Our H-3,4-Dehydro-Pro-Nh2 Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.