Description

(Nle8,18,Tyr34)-Pth (1-34) Amide (Bovine) CAS NO 64763-77-5 is a synthetic, biologically active peptide fragment of bovine parathyroid hormone. This high-purity analog is engineered for enhanced stability and consistent biological activity, making it a critical reagent for advanced research and development. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic manufacturers focused on bone metabolism, calcium regulation, and endocrine system studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active ingredient in preclinical studies for osteoporosis and hyperparathyroidism treatments.
• Biochemical Assay Development: Used as a calibrated antigen or ligand in the development and validation of immunoassays (e.g., ELISA, RIA) for PTH-related studies.
• Cell Biology & Signal Transduction Studies: Employed to investigate the PTH/PTHrP receptor signaling pathways and their role in bone and mineral homeostasis.
• Quality Control & Standardization: Acts as a primary standard for the quality control of diagnostic kits and calibration of analytical instruments in clinical laboratories.
• Academic Research: A vital tool for university and institutional research exploring endocrine physiology, peptide hormone structure-activity relationships, and metabolic disorders.
• Peptide Chemistry & Analog Synthesis: Used as a starting point or benchmark for the design and synthesis of novel PTH analogs with modified pharmacological profiles.

Basic Information

Product Name	(Nle8,18,Tyr34)-Pth (1-34) Amide (Bovine)
CAS No.	64763-77-5
Molecular Formula	C181H291N55O51
Molecular Weight	~4107.6 g/mol
Synonyms	Bovine PTH (1-34) amide, [Nle8,18,Tyr34]-bPTH(1-34)-NH2; Parathyroid Hormone (1-34), bovine, analog; Nle8,18,Tyr34-bPTH(1-34) amide; bPTH(1-34) amide analog; CAS 64763-77-5; PTH fragment 1-34 (bovine); [Nle8,Nle18,Tyr34]bPTH-(1-34)-amide
EINECS	Contact for details

Quality Control

Our (Nle8,18,Tyr34)-Pth (1-34) Amide (Bovine) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles to ensure it meets the exacting standards required for pharmaceutical research and bioassay applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.