Description

2-Bromo-4,5-Difluoroaniline is a halogenated aniline derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on the aromatic ring, makes it an essential intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoro and bromo groups can enhance binding affinity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, halogenated dyes and pigments with specific color fastness and light-absorption properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct biaryl and other complex structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-4,5-Difluoroaniline
CAS No.	64695-79-0
Molecular Formula	C6H4BrF2N
Molecular Weight	208.00 g/mol
Synonyms	4,5-Difluoro-2-bromoaniline; 2-Bromo-4,5-difluorobenzenamine; Benzenamine, 2-bromo-4,5-difluoro-; 2-Bromo-4,5-difluoro-phenylamine; 2-Bromo-4,5-difluoroaniline; 64695-79-0; 4,5-Difluoro-2-bromo-aniline; 2-Br-4,5-F2-C6H2-NH2
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-Difluoroaniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.