Description

Tfa-Val-Tyr-Val-Oh CAS NO 64577-63-5 is a synthetic, protected tetrapeptide derivative featuring trifluoroacetyl (Tfa) and terminal carboxylic acid (OH) groups. This compound serves as a crucial building block (intermediate) in advanced peptide synthesis, offering precise control over molecular structure for research and development. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a standardized intermediate in studying peptide structure-activity relationships (SAR), enzyme substrates, or inhibitors.
• Proteomics & Diagnostics: Serves as a component in the development of specialized reagents, affinity tags, or calibration standards for analytical systems.
• Custom Peptide Synthesis: An essential protected fragment for contract research organizations (CROs) and CDMOs producing custom peptides on a commercial scale.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis projects and methodology development in peptide chemistry.

Basic Information

Product Name	Tfa-Val-Tyr-Val-Oh
CAS No.	64577-63-5
Molecular Formula	C24H32F3N3O6
Molecular Weight	515.52 g/mol
Synonyms	Nα-Trifluoroacetyl-L-valyl-L-tyrosyl-L-valine; TFA-Val-Tyr-Val-OH; Trifluoroacetylvalyltyrosylvaline; N-TFA-Val-Tyr-Val-OH; L-Valine, N-[N-[N2-[(trifluoroacetyl)-L-valyl]-L-tyrosyl]-L-valyl]-; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3,3,3-trifluoropropanoic acid; Protected VYV Tetrapeptide; Tfa-V-Y-V-OH
EINECS	Contact for details

Quality Control

Our Tfa-Val-Tyr-Val-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets exacting R&D and cGMP-grade standards for use as a pharmaceutical intermediate. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.