Description

1-Oxo-5,6-Dihydro-1H-Pyrimido[1,2-A]Quinoline-2-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, or oncology.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex polycyclic frameworks due to its reactive ester and ketone functionalities.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial API batches.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-Oxo-5,6-Dihydro-1H-Pyrimido[1,2-A]Quinoline-2-Carboxylic Acid Methyl Ester
CAS No.	64399-33-3
Molecular Formula	C15H12N2O3
Molecular Weight	268.27 g/mol
Synonyms	Methyl 1-oxo-5,6-dihydro-1H-pyrimido[1,2-a]quinoline-2-carboxylate; 1H-Pyrimido[1,2-a]quinoline-2-carboxylic acid, 5,6-dihydro-1-oxo-, methyl ester; Pyrimidoquinolone derivative; 64399-33-3; Quinoline, 1-oxo-5,6-dihydro-1H-pyrimido[1,2-a]-, 2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Oxo-5,6-Dihydro-1H-Pyrimido[1,2-A]Quinoline-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.