Description

n-Bromoacetylthyroxine is a chemically modified derivative of the thyroid hormone thyroxine, specifically functionalized with a bromoacetyl group. This modification is crucial for its primary role as a key synthetic intermediate in the research and development of novel thyroid hormone analogs and diagnostic agents. It is particularly valuable for pharmaceutical researchers and fine chemical manufacturers engaged in endocrinology and metabolic disorder studies. The compound's reactive bromoacetyl moiety allows for targeted conjugation, making it essential for creating labeled probes and potential therapeutic candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel thyroid hormone receptor agonists, antagonists, and metabolically stable analogs for therapeutic development.
• Biochemical Research: Used in academic and industrial laboratories to study thyroid hormone action, receptor binding affinity, and metabolic pathways.
• Diagnostic Agent Synthesis: Serves as a precursor for radiolabeled or fluorescently tagged compounds used in imaging and diagnostic assays.
• Conjugation Chemistry: The reactive bromoacetyl group enables covalent attachment to proteins, peptides, or other carriers for creating immunogens or targeted delivery systems.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for related pharmaceutical products.
• Chemical Biology Probes: Utilized to develop activity-based probes for investigating enzyme function and signaling pathways related to thyroid hormone metabolism.

Basic Information

Product Name	n-Bromoacetylthyroxine
CAS No.	64379-24-4
Molecular Formula	C₁₅H₁₁BrI₄NO₄
Molecular Weight	888.77 g/mol
Synonyms	Bromoacetylthyroxine; Thyroxine, bromoacetate; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-4-bromoacetoxy-L-phenylalanine; N-Bromoacetyl-L-thyroxine; Bromoacetyl thyroxine; L-Thyroxine, bromoacetate; Bromoacetylated thyroxine; T4-bromoacetate
EINECS	Contact for details

Quality Control

Our n-Bromoacetylthyroxine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.