Description

tert-Butyloxycarbonyl-Valyl-Glycyl-Arginine-2-Naphthylamide is a synthetic peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a specialized substrate for studying protease and peptidase enzyme activity, particularly in high-throughput screening and mechanistic studies. It is essential for researchers and manufacturers in the fields of pharmaceutical R&D, proteomics, and diagnostic assay development who require high-purity, well-characterized biochemical tools.

Application

• Protease/Peptidase Substrate: Used as a chromogenic or fluorogenic substrate for the detection and kinetic analysis of specific enzyme activities, such as trypsin-like proteases.
• Biochemical Research: A critical tool in enzymology for investigating enzyme mechanisms, inhibition, and substrate specificity.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify and characterize potential therapeutic enzyme inhibitors.
• Diagnostic Development: Utilized in the development of clinical diagnostic kits for detecting specific enzymatic markers.
• Peptide Chemistry Intermediate: Serves as a protected peptide building block for the synthesis of more complex peptide structures.

Basic Information

Product Name	tert-Butyloxycarbonyl-Valyl-Glycyl-Arginine-2-Naphthylamide
CAS No.	64309-42-8
Molecular Formula	C₂₈H₄₅N₉O₆
Molecular Weight	603.73 g/mol
Synonyms	Boc-Val-Gly-Arg-2NA; Boc-Val-Gly-Arg-βNA; BOC-VGR-2-NA; tert-Butoxycarbonyl-Valyl-Glycyl-Arginine-2-Naphthylamide; Nα-(tert-Butoxycarbonyl)-L-valylglycyl-L-arginine 2-naphthylamide; Val-Gly-Arg-2-Naphthylamide, Boc-protected; Protease Substrate VGR-2NA; 64309-42-8
EINECS	Contact for details

Quality Control

Our tert-Butyloxycarbonyl-Valyl-Glycyl-Arginine-2-Naphthylamide is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and chiral analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.