Description

(Nle8,18,Tyr34)-Pth (3-34) Amide (Bovine) is a synthetic peptide fragment of bovine parathyroid hormone (PTH). This compound is a critical research tool for studying the structure-activity relationships of PTH, particularly its interaction with the PTH1 receptor. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic bone disease research, peptide hormone studies, and drug discovery programs targeting osteoporosis and hyperparathyroidism.

Application

• Biochemical Research: A key reference standard for investigating the biological activity and receptor binding mechanisms of parathyroid hormone.
• Drug Discovery: Used in high-throughput screening assays to identify and characterize novel PTH receptor agonists or antagonists for therapeutic development.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the active regions of PTH by comparing the activity of this fragment with the full-length hormone and other analogs.
• In Vitro & Ex Vivo Studies: Applied in cell-based assays and tissue culture models to study calcium homeostasis and bone metabolism pathways.
• Antibody Production & Immunoassays: Can serve as an antigen for generating specific antibodies or as a calibrator in immunoassay development for PTH-related research.
• Academic & Pharmaceutical R&D: Supports fundamental and applied research in endocrinology, bone biology, and peptide engineering.

Basic Information

Product Name	(Nle8,18,Tyr34)-Pth (3-34) Amide (Bovine)
CAS No.	64297-16-1
Molecular Formula	C178H288N52O51
Molecular Weight	3979.5 g/mol (theoretical)
Synonyms	PTH (3-34) amide, bovine; [Nle8,18, Tyr34]-bPTH(3-34) amide; Bovine Parathyroid Hormone (3-34) fragment amide; Parathyroid Hormone Fragment (3-34); bPTH(3-34)NH2; PTH-related protein analog; PTH receptor ligand; PTH antagonist research compound
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality systems. Each batch of (Nle8,18,Tyr34)-Pth (3-34) Amide (Bovine) undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We support research requiring high-purity, well-characterized biochemicals, and specifications can be aligned with specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.