Description

Enkephalin, Met(2)-Pro(5)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified at the second and fifth amino acid positions. This compound is of significant interest in neuroscience and pharmaceutical research for its role in studying opioid receptor interactions and pain modulation pathways. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in neuropharmacology, analgesic drug discovery, and biochemical assay development.

Application

• Neuroscience Research: As a tool compound for investigating the function and binding characteristics of delta and mu opioid receptors.
• Analgesic Drug Development: Serving as a reference standard or lead structure in the design of novel, non-addictive pain therapeutics.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional cellular tests to screen for opioid activity.
• Academic Studies: Fundamental research on endogenous opioid systems, peptide metabolism, and signal transduction mechanisms.
• Pharmaceutical Reference Standard: Qualification and calibration standard for quality control in peptide-based pharmaceutical manufacturing.

Basic Information

Product Name	Enkephalin, Met(2)-Pro(5)-
CAS No.	64267-98-7
Molecular Formula	C28H35N5O7S
Molecular Weight	585.67 g/mol
Synonyms	[Met2, Pro5]-Enkephalin; H-Tyr-Gly-Gly-Phe-Met-OH (modified); Methionine Enkephalin, Proline-substituted; Opioid Peptide Analog; YGGFM-Pro analog; (2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoic acid; 64267-98-7
EINECS	Contact for details

Quality Control

Our Enkephalin, Met(2)-Pro(5)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to specific purity levels (e.g., >95%, >98%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.