Description

(D-Ala2,Nle5)-Enkephalin is a synthetic, biologically active peptide analog of the endogenous opioid peptide enkephalin. This compound is of significant value in neuroscience and pharmacological research due to its potent and selective activity at opioid receptors, offering enhanced metabolic stability compared to its natural counterparts. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies for applications in neurobiology, pain mechanism studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Used as a selective tool compound to study the function and signaling pathways of δ-opioid receptors (DOR) in the central nervous system.
• Pharmacological Assays: Serves as a reference standard or active agent in in vitro and in vivo assays to evaluate analgesic efficacy and receptor binding affinity.
• Drug Discovery: A key intermediate or model peptide in the development of new analgesic drugs with improved stability and reduced side-effect profiles.
• Biochemical Studies: Employed to investigate peptide-receptor interactions, structure-activity relationships (SAR), and the enzymatic degradation of neuropeptides.
• Cell Signaling Research: Utilized to activate specific opioid receptor subtypes to study downstream cellular effects and G-protein coupling.

Basic Information

Product Name	(D-Ala2,Nle5)-Enkephalin
CAS No.	64267-91-0
Molecular Formula	C30H41N5O7
Molecular Weight	583.68 g/mol
Synonyms	DADLE; [D-Ala2, Leu5]-Enkephalin; [D-Ala2, D-Leu5]-Enkephalin; Tyr-D-Ala-Gly-Phe-D-Leu; H-Tyr-D-Ala-Gly-Phe-Leu-OH; [D-Ala2,Leu5]enkephalin; Delta opioid receptor agonist DADLE; (D-Ala2,Leu5)-Enkephalin
EINECS	Contact for details

Quality Control

Our (D-Ala2,Nle5)-Enkephalin is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for manufacturing and quality management to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.