Description

4-Fluoro-L-Phenylalanine Hydrochloride is a fluorinated derivative of the essential amino acid L-phenylalanine, supplied as a stable hydrochloride salt. This compound is a critical building block in pharmaceutical research and development, particularly for the synthesis of novel peptides and active pharmaceutical ingredients (APIs). It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors who require high-purity, non-natural amino acids for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide-based drugs and APIs.
• Proteomics & Biochemistry Research: Used in metabolic pathway studies and as a labeled amino acid analog in biochemical assays.
• PET (Positron Emission Tomography) Tracer Development: Serves as a precursor for fluorine-18 labeled radiopharmaceuticals used in medical imaging.
• Peptide Synthesis: Incorporated into custom peptides to modulate their biological activity, stability, and pharmacokinetic properties.
• Enzyme Substrate & Inhibitor Studies: Utilized to investigate enzyme specificity and mechanism due to the fluorine atom's electronic effects.
• Material Science: Potential monomer for creating specialized polymers and advanced materials with unique properties.

Basic Information

Product Name	4-Fluoro-L-Phenylalanine Hydrochloride
CAS No.	64231-54-5
Molecular Formula	C9H11FNO2 • HCl
Molecular Weight	219.65 g/mol
Synonyms	(S)-2-Amino-3-(4-fluorophenyl)propanoic acid hydrochloride; L-4-Fluorophenylalanine hydrochloride; F-Phe-OH • HCl; p-Fluoro-L-phenylalanine HCl; 4-F-L-Phe-HCl; (2S)-2-Azaniumyl-3-(4-fluorophenyl)propanoate chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-L-Phenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.