Description

γ-Carboxyglutamyl-γ-Carboxyglutamic Acid is a specialized peptide derivative of glutamic acid, featuring two γ-carboxylated glutamyl residues. This compound is of significant interest in biochemical research and pharmaceutical development due to its structural similarity to key motifs found in vitamin K-dependent proteins involved in blood coagulation and bone metabolism. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in the study of calcium-binding proteins, anticoagulant pathways, and metabolic bone disorders.

Application

• Biochemical Research: Used as a reference standard or substrate in studies of vitamin K-dependent carboxylation enzymes (e.g., γ-glutamyl carboxylase).
• Pharmaceutical Development: Serves as a key intermediate or model compound for developing therapeutics targeting blood coagulation disorders like hemophilia or thrombosis.
• Diagnostic Reagents: Employed in the formulation of calibration standards or assay components for clinical tests measuring undercarboxylated osteocalcin or other bone turnover markers.
• Metabolic Studies: Acts as a probe to investigate the role of γ-carboxyglutamic acid (Gla) residues in calcium ion binding and mineralized tissue formation.
• Nutraceutical Research: Investigated for potential applications in bone health supplements, given the role of Gla proteins in bone matrix.

Basic Information

Product Name	γ-Carboxyglutamyl-γ-Carboxyglutamic Acid
CAS No.	64153-41-9
Molecular Formula	C10H12N2O10
Molecular Weight	320.21 g/mol
Synonyms	Bis(γ-carboxyglutamyl)glutamic acid; Gla-Gla-Glu; γ-Gla-γ-Gla; N-(4-Carboxy-4-oxobutyl)-L-glutamic acid 1,5-bis(1-ethyl ester); L-γ-Glutamyl-L-glutamic acid, 1,1'-(oxybis(carbonyl))bis[4-carboxy-]; (2S)-2-[[(4S)-4-Carboxy-4-[[(4S)-4-carboxy-4-(carboxymethylamino)-1-hydroxy-4-oxobutan-2-yl]amino]-1-hydroxy-4-oxobutan-2-yl]amino]pentanedioic acid
EINECS	Contact for details

Quality Control

Our γ-Carboxyglutamyl-γ-Carboxyglutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for related substances and residual solvents. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. Our quality commitment ensures material suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.