Description

Pglu-His-Pro Amide Trifluoroacetate is a high-purity synthetic peptide derivative, specifically the trifluoroacetate salt of the pyroglutamyl-histidyl-proline amide. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and peptide synthesis. It is primarily utilized by research institutions and pharmaceutical developers working on neuroendocrine pathways, metabolic studies, and novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, MS) and quality control in drug development.
• Biochemical Research: Serves as a key reagent in studies of thyrotropin-releasing hormone (TRH) analogs and related neuropeptides.
• Peptide Synthesis Intermediate: An essential building block for the solid-phase or solution-phase synthesis of more complex peptide sequences.
• Metabolic & Endocrine Studies: Applied in in vitro and in vivo research to investigate hormonal regulation and signaling pathways.
• Active Pharmaceutical Ingredient (API) Development: Investigated for potential use in the formulation of peptide-based therapeutics.

Basic Information

Product Name	Pglu-His-Pro Amide Trifluoroacetate
CAS No.	64134-15-2
Molecular Formula	C19H25F3N6O5
Molecular Weight	474.43 g/mol
Synonyms	Pyroglutamyl-histidyl-prolinamide trifluoroacetate; TRH Amide TFA salt; pGlu-His-Pro-NH2 · TFA; L-Pyroglutamyl-L-histidyl-L-prolinamide trifluoroacetate; (pyro)Glu-His-Pro-NH2 TFA; Thyrotropin-Releasing Hormone Amide TFA; 5-Oxo-L-prolyl-L-histidyl-L-prolinamide trifluoroacetate
EINECS	Contact for details

Quality Control

Our Pglu-His-Pro Amide Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.