Description

Neurotensin, Phe(11)- CAS NO 64088-66-0 is a synthetic peptide analog of the endogenous neuropeptide neurotensin, specifically modified at the 11th position with a phenylalanine residue. This modification is crucial for studying structure-activity relationships, enhancing receptor binding affinity, and improving metabolic stability in research applications. It is an essential tool for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery, particularly for investigating neurotensin receptor-mediated pathways and developing novel therapeutic agents.

Application

• Neuroscientific Research: Used as a key reagent to study the role of neurotensin in the central nervous system, including its effects on dopamine transmission, pain modulation, and thermoregulation.
• Pharmacology & Drug Discovery: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of neurotensin receptor (NTS1/NTS2) agonists and antagonists for potential therapies targeting schizophrenia, addiction, and cancer.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, receptor binding studies, and functional cellular assays to identify new drug candidates.
• Academic & Institutional Research: Provides a critical tool for universities and research institutes exploring peptide hormone signaling, G-protein coupled receptor (GPCR) function, and peptide stability.
• In Vitro Diagnostics (IVD): Can be utilized as a calibrator or component in the development of diagnostic kits for research purposes related to neuroendocrine functions.

Basic Information

Product Name	Neurotensin, Phe(11)- CAS NO 64088-66-0
CAS No.	64088-66-0
Molecular Formula	C₈₀H₁₂₂N₂₄O₂₂
Molecular Weight	1796.0 g/mol (approximate)
Synonyms	Phe(11)-Neurotensin; [Phe11]-Neurotensin; Neurotensin (8-13), Phe(11)-; Neurotensin fragment 8-13, [Phe11]-; H-Arg-Arg-Pro-Tyr-Ile-Leu-Phe-OH; NT(8-13), [Phe11]-; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Phe-Leu-OH (Phe11 variant)
EINECS	Contact for details

Quality Control

Our Neurotensin, Phe(11)- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to stringent analytical protocols using techniques such as HPLC and mass spectrometry to verify product integrity. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the peptide desiccated at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.