Description

3β-[2-(Acetyloxy)-1-Oxopropoxy]-5,14-Dihydroxy-19-Oxo-5β-Card-20(22)-Enolide is a high-purity, semi-synthetic cardiac glycoside derivative of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel cardioprotective agents and for structure-activity relationship (SAR) studies. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on cardiovascular drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel cardiac glycosides and related therapeutic agents.
• Cardiovascular Research: Used in biochemical and pharmacological studies to investigate mechanisms of cardiac ion channel modulation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Structure-Activity Relationship (SAR) Studies: Crucial for medicinal chemistry programs aimed at optimizing potency and selectivity of cardiotonic drugs.
• Active Pharmaceutical Ingredient (API) Development: Employed in the development and scale-up processes for new chemical entities (NCEs) targeting heart failure.
• Biochemical Assays: Utilized as a ligand or substrate in high-throughput screening (HTS) and in vitro assays.

Basic Information

Product Name	3β-[2-(Acetyloxy)-1-Oxopropoxy]-5,14-Dihydroxy-19-Oxo-5β-Card-20(22)-Enolide
CAS No.	63979-64-6
Molecular Formula	C30H40O10
Molecular Weight	560.64 g/mol
Synonyms	3β-[2-(Acetyloxy)-1-oxopropoxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide; 3β-(2-Acetoxypropionyloxy)-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide; Acetylgitoxin impurity; Gitoxin acetate derivative; 19-Oxogitoxin 3-acetate; 3β-Acetoxypropionylgitoxigenin; Cardiac glycoside intermediate 63979-64-6
EINECS	Contact for details

Quality Control

Our 3β-[2-(Acetyloxy)-1-Oxopropoxy]-5,14-Dihydroxy-19-Oxo-5β-Card-20(22)-Enolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.