Description

Neurotensin, Arg(9)- CAS NO 63770-62-7 is a synthetic peptide analog of the endogenous neuropeptide neurotensin, specifically modified at the ninth amino acid position with an arginine residue. This modification is critical for enhancing its stability and receptor binding affinity, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, endocrinology, and drug discovery programs.

Application

• Neuroscience Research: Used as a potent agonist to study the role of neurotensin receptors (NTS1 and NTS2) in the central nervous system, including their involvement in dopamine modulation, pain perception, and thermoregulation.
• Pharmacological Studies: Serves as a reference standard and active agent in high-throughput screening (HTS) assays to identify and characterize novel neurotensin receptor modulators for therapeutic development.
• Biochemical Assays: Employed in receptor binding studies, signal transduction pathway analysis (e.g., calcium mobilization, cAMP inhibition), and autoradiography to map receptor distribution.
• Drug Discovery & Development: Acts as a key intermediate or biological tool in the preclinical development of potential therapeutics for psychiatric disorders (e.g., schizophrenia), pain management, and metabolic diseases.
• Academic & Institutional Research: Fundamental research tool for investigating neurotensin's physiological roles in the gastrointestinal tract and its potential links to cancer cell proliferation.

Basic Information

Product Name	Neurotensin, Arg(9)-
CAS No.	63770-62-7
Molecular Formula	C78H121N25O21
Molecular Weight	1760.0 g/mol (theoretical)
Synonyms	Arg(9)-Neurotensin; [Arg9]-Neurotensin; Neurotensin (8-13), Arg(9)-; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu; NT(8-13), Arg(9)-; Neurotensin fragment 8-13, Arg(9)-substituted; H-Arg-Arg-Pro-Tyr-Ile-Leu-OH (related fragment); NTS (8-13) analog
EINECS	Contact for details

Quality Control

Our Neurotensin, Arg(9)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, peptide content, water content (by KF), and residual solvent analysis. Our quality commitment ensures the material is suitable for sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.