Description

R(+)-Baclofen Hydrochloride is the pharmacologically active enantiomer of the muscle relaxant Baclofen, specifically formulated as its stable hydrochloride salt. This high-purity chiral intermediate is critical for advanced pharmaceutical research and development, particularly in neuroscience and pain management. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on developing enantiomerically pure therapeutics.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as the key chiral building block for the production of enantiopure Baclofen and related therapeutic agents.
• Neurological Research: Used as a reference standard and active compound in preclinical studies targeting GABAB receptor function, spasticity, and neuropathic pain.
• Analytical Standard Development: Employed in HPLC and LC-MS methods for method validation, quality control, and impurity profiling of Baclofen-based pharmaceuticals.
• Asymmetric Synthesis Studies: Acts as a model compound in research exploring new chiral resolution techniques and asymmetric catalytic processes.
• Formulation Development: Utilized in the development of novel drug delivery systems, such as controlled-release formulations or intrathecal delivery solutions.

Basic Information

Product Name	R(+)-Baclofen Hydrochloride
CAS No.	63701-55-3
Molecular Formula	C10H12ClNO2 • HCl
Molecular Weight	250.12 g/mol
Synonyms	(R)-Baclofen HCl; (+)-Baclofen Hydrochloride; (R)-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid hydrochloride; (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid hydrochloride; (R)-β-(4-Chlorophenyl)-GABA hydrochloride; Lioresal (enantiopure form); GABAB receptor agonist (R-enantiomer); Baclofen (R-isomer) hydrochloride
EINECS	Contact for details

Quality Control

Our R(+)-Baclofen Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity (typically >98.5% by HPLC), enantiomeric excess (typically >99.0% ee), and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.