Description

H-Phe-Leu-Obzl CAS NO 63649-15-0 is a protected dipeptide derivative, specifically the benzyl ester of the phenylalanine-leucine dipeptide. This compound serves as a crucial building block (synthon) in advanced organic synthesis, particularly for constructing complex peptide chains with precise stereochemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key raw material in the multi-step synthesis of potential peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry Research: Used as a protected fragment in solid-phase and solution-phase peptide synthesis (SPPS) to study structure-activity relationships.
• Biochemical Tool Development: Employed in the design and synthesis of enzyme substrates, inhibitors, or probes for biochemical assays.
• Academic & Institutional R&D: Serves as a standard or starting material in university and research institute laboratories for organic and medicinal chemistry projects.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	H-Phe-Leu-Obzl
CAS No.	63649-15-0
Molecular Formula	C23H28N2O4
Molecular Weight	396.48 g/mol
Synonyms	L-Phenylalanyl-L-leucine benzyl ester; Benzyl L-phenylalanyl-L-leucinate; H-Phe-Leu-OBzl; Phe-Leu-OBzl; N-(Benzyloxycarbonyl)-L-phenylalanyl-L-leucine benzyl ester (related protected form); Z-Phe-Leu-OBzl (common abbreviation); Fmoc-Phe-Leu-OBzl (common abbreviation for Fmoc-protected variant); L-Phe-L-Leu-OBzl
EINECS	Contact for details

Quality Control

Our H-Phe-Leu-Obzl is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity, meeting the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting identity, purity (assay), and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.