Description

H-Tyr-D-Ala-Gly-Phe-D-Leu-Oh is a synthetic pentapeptide with the CAS number 63631-40-3, featuring a unique sequence of D- and L-amino acids. This compound is of significant interest in pharmaceutical research and development due to its structural similarity to endogenous opioid peptides. It serves as a critical intermediate and reference standard for researchers in the fields of neuropharmacology, peptide chemistry, and drug discovery. The product is essential for laboratories and manufacturers focused on developing novel therapeutics targeting pain management and neurological disorders.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel opioid peptide analogs and receptor ligands.
• Biochemical Studies: Used as a reference standard or substrate in enzymatic assays and receptor binding studies to investigate opioid pathways.
• Peptide Library Construction: A valuable building block for creating combinatorial peptide libraries to screen for biological activity.
• Academic Research: Fundamental tool for studying structure-activity relationships (SAR) of peptide hormones and neurotransmitters.
• Drug Discovery: Serves as a starting material or a comparative compound in the development of new analgesic or neuroactive drugs.
• Quality Control: Employed as an analytical reference standard for the identification and quantification of related peptide substances.

Basic Information

Product Name	H-Tyr-D-Ala-Gly-Phe-D-Leu-Oh
CAS No.	63631-40-3
Molecular Formula	C31H42N6O7
Molecular Weight	610.70 g/mol
Synonyms	Tyr-D-Ala-Gly-Phe-D-Leu-OH; Tyr-D-Ala-Gly-Phe-D-Leu; DADLE (D-Ala2, D-Leu5)-Enkephalin; [D-Ala2, D-Leu5]-Enkephalin; H-Tyr-D-Ala-Gly-Phe-D-Leu-OH; YAGFDL-OH; Opioid peptide DADLE; Delta opioid receptor agonist peptide; 63631-40-3
EINECS	Contact for details

Quality Control

Our H-Tyr-D-Ala-Gly-Phe-D-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure the correct stereochemistry. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data on purity, residual solvents, and other critical parameters. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity (HPLC)	≥ 99.0% for D-amino acids

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.