Description

4,4-Dimethyl-Proline is a non-proteinogenic, cyclic amino acid derivative characterized by its unique gem-dimethyl substitution at the 4-position of the proline ring. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is particularly sought after by research institutions and pharmaceutical companies for applications in medicinal chemistry, peptide mimetics, and as a precursor for novel bioactive compounds. The compound's defined stereochemistry and high purity are critical for ensuring reproducible results in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for modifying peptide stability and bioavailability.
• Peptide Chemistry: Used in the synthesis of conformationally constrained peptides and peptidomimetics to study structure-activity relationships.
• Asymmetric Synthesis: Acts as a precursor or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Biochemical Research: Employed as a probe or substrate in enzymatic studies and metabolic pathway investigations.
• Agrochemical Development: Potential use as an intermediate in the synthesis of novel, biologically active compounds for crop protection.
• Material Science: Exploration as a monomer or functional additive for creating specialized polymers with unique properties.

Basic Information

Product Name	4,4-Dimethyl-Proline
CAS No.	63624-41-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	4,4-Dimethylpyrrolidine-2-carboxylic acid; (S)-4,4-Dimethylproline; 4,4-Dimethyl-L-proline; 4-Cyano-4-methyl-L-proline methyl ester (precursor); 2-Pyrrolidinecarboxylic acid, 4,4-dimethyl-; 4,4-DMP; 4,4-Dimethylproline hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from methods including HPLC, chiral analysis, and NMR. While produced to high standards suitable for research and development, specifications can be aligned with specific project requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.