Description

Neurotensin (1-10) is a bioactive peptide fragment corresponding to the first ten amino acids of the full-length neurotensin hormone. This specific sequence is crucial for research into receptor binding and signal transduction mechanisms, offering a valuable tool for studying neurological and gastrointestinal functions. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuropeptide pharmacology and drug discovery.

Application

• Neuroscientific Research: Used as a reference standard and active agent in studies of neurotensin receptor (NTS1/NTS2) binding, localization, and function.
• Pharmacological Assay Development: Serves as a key ligand in high-throughput screening (HTS) campaigns to identify novel agonists or antagonists.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to map the active regions of the neurotensin peptide.
• Cell Signaling Research: Applied in vitro to investigate downstream signaling pathways, such as calcium mobilization and MAPK/ERK activation.
• Prototypic Drug Candidate: Acts as a lead compound for the development of potential therapeutics targeting neurological disorders, pain, and cancer.

Basic Information

Product Name	Neurotensin (1-10)
CAS No.	63524-00-5
Molecular Formula	C53H83N17O13
Molecular Weight	1158.34 g/mol
Synonyms	NT (1-10); Neurotensin 1-10; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro; Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro; H-Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-OH; L-Pyroglutamyl-L-leucyl-L-tyrosyl-L-α-glutamyl-L-α-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-proline
EINECS	Contact for details

Quality Control

Every batch of Neurotensin (1-10) is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.