Description

H-α-Me-D-Pro-Oh CAS NO 63399-77-9 is a high-purity, non-proteinogenic amino acid derivative, specifically a methylated D-proline analog. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling precise control over molecular conformation and biological activity. It is essential for research and development laboratories in the pharmaceutical, biotechnology, and agrochemical sectors focused on peptide mimetics, drug discovery, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and receptor modulator research.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and binding affinity for therapeutic candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst ligand in stereoselective chemical transformations to produce enantiomerically pure compounds.
• Agrochemical Research: Acts as a building block for designing novel, biologically active compounds with specific modes of action.
• Biochemical Research: Utilized in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Material Science: Potential monomer for creating specialized polymers with unique structural properties.

Basic Information

Product Name	H-α-Me-D-Pro-Oh
CAS No.	63399-77-9
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(2R)-2-Methylpyrrolidine-2-carboxylic acid; D-2-Methylproline; (R)-2-Methylproline; D-α-Methylproline; H-D-α-Me-Pro-OH; (R)-2-Methylpyrrolidine-2-carboxylic acid; α-Methyl-D-proline; D-2-Methyl-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our H-α-Me-D-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98% by HPLC), and related substances is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.