Description

1-Propargyl-5-Bromopyrimidin-2-One is a specialized heterocyclic building block featuring both a bromo and a propargyl functional group. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for applications such as targeted synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probe Synthesis: The propargyl group enables click chemistry (e.g., CuAAC) for bioconjugation and labeling applications.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and library synthesis in drug discovery projects.

Basic Information

Product Name	1-Propargyl-5-Bromopyrimidin-2-One
CAS No.	63331-28-2
Molecular Formula	C7H5BrN2O
Molecular Weight	213.03 g/mol
Synonyms	5-Bromo-1-(prop-2-yn-1-yl)pyrimidin-2(1H)-one; 5-Bromo-1-propargylpyrimidin-2(1H)-one; 1-Propargyl-5-bromouracil; 5-Bromo-1-(2-propynyl)-2-pyrimidinone; 5-Bromo-1-(prop-2-ynyl)pyrimidin-2-one; 63331-28-2; 5-Bromo-1-propargyl-1H-pyrimidin-2-one
EINECS	Contact for details

Quality Control

Our 1-Propargyl-5-Bromopyrimidin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.