Description

1-Propargyl-5-Chloropyrimidin-2-One is a specialized heterocyclic building block featuring both a propargyl and a chloro substituent on a pyrimidinone core. This unique molecular structure makes it a valuable intermediate for the synthesis of more complex pharmacologically active compounds and advanced materials. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, or insecticides that require a functionalized pyrimidine scaffold.
• Chemical Biology Probe Development: The propargyl group enables click chemistry (e.g., CuAAC reactions) for labeling and studying biological systems.
• Material Science Research: Serves as a precursor for constructing functional organic molecules used in electronic or optical materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and heterocyclic chemistry exploration.
• Custom Synthesis Building Block: Supplied to fine chemical companies for the tailored production of client-specific compounds.

Basic Information

Product Name	1-Propargyl-5-Chloropyrimidin-2-One
CAS No.	63331-26-0
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	5-Chloro-1-(prop-2-yn-1-yl)pyrimidin-2(1H)-one; 5-Chloro-1-propargyl-1,2-dihydropyrimidin-2-one; 1-Propargyl-5-chloro-2-pyrimidinone; 2(1H)-Pyrimidinone, 5-chloro-1-(2-propynyl)-; 5-Chloro-1-(prop-2-ynyl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 1-Propargyl-5-Chloropyrimidin-2-One is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.