Description

H-D-Leu-Pna CAS NO 63324-49-2 is a high-purity, protected amino acid derivative specifically designed for peptide synthesis and pharmaceutical research. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide sequences with defined stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for developing novel therapeutic agents and bioactive peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected leucine derivative for the sequential assembly of peptides.
• Pharmaceutical Intermediate: For the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used in the synthesis of peptide-protein conjugates for diagnostic and therapeutic applications.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening and drug discovery.
• Biochemical Research: As a substrate or inhibitor in enzymatic studies and proteomics research.
• Fine Chemical Synthesis: For the preparation of specialized chiral compounds and complex organic molecules.

Basic Information

Product Name	H-D-Leu-Pna
CAS No.	63324-49-2
Molecular Formula	C12H17N3O3
Molecular Weight	251.28 g/mol
Synonyms	H-D-Leu-pNA; D-Leucine p-nitroanilide; (R)-2-Amino-4-methylpentanoic acid 4-nitroanilide; N-(4-Nitrophenyl)-D-leucinamide; D-Leu-pNA; p-Nitroanilide of D-leucine; D-Leu-p-nitroanilide; Boc-D-Leu-pNA (when protected)
EINECS	Contact for details

Quality Control

Our H-D-Leu-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.