Description

Secretin, -Tyr(10)- is a synthetic peptide analog of the gastrointestinal hormone secretin, specifically modified at the tenth amino acid position with a tyrosine residue. This modification can enhance its stability and binding affinity for research into digestive physiology and related disorders. It is a critical tool for researchers and developers in the fields of endocrinology and metabolic disease. This product, identified by CAS No. 63220-78-0, is essential for high-precision biochemical assays and pharmaceutical development.

Application

• Biomedical Research: Used as a molecular probe to study secretin receptor (SCTR) signaling pathways, activation mechanisms, and downstream effects.
• Drug Discovery & Development: Serves as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of therapeutics for pancreatic and gastrointestinal disorders.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to measure secretin levels or receptor activity.
• Physiological Studies: Applied in in vitro and in vivo models to investigate the regulation of bicarbonate secretion, gastric acid inhibition, and pancreatic exocrine function.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on endocrinology, neurogastroenterology, and peptide hormone biology.

Basic Information

Product Name	Secretin, -Tyr(10)-
CAS No.	63220-78-0
Molecular Formula	C130H220N44O41
Molecular Weight	3055.4 g/mol
Synonyms	Secretin (10-Tyrosine); [Tyr10]-Secretin; H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2; Secretin, Tyr(10)-; Secretin human, 10-Tyr-; 10-Tyrosine-secretin; Secretin (human) (10-Tyr)
EINECS	Contact for details

Quality Control

Our Secretin, -Tyr(10)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak matches theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.