Description

Enkephalin-Met, Trp(4)- CAS NO 63074-20-4 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified with a tryptophan substitution at position 4. This compound is of significant value in neuroscience and pharmaceutical research for its role in studying opioid receptor interactions, pain modulation pathways, and peptide stability. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuropharmacology, analgesic drug discovery, and biochemical assay development.

Application

• Neuroscience Research: Used as a tool compound to investigate the binding affinity and functional activity of delta and mu opioid receptors.
• Analgesic Drug Development: Serves as a reference standard or lead compound in the discovery and optimization of novel, non-addictive pain therapeutics.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and signal transduction studies to elucidate opioid system mechanisms.
• Peptide Structure-Activity Relationship (SAR) Studies: The Trp(4) modification makes it a key molecule for studying the impact of aromatic residue substitution on peptide conformation, receptor selectivity, and metabolic stability.
• Academic & Pharmaceutical R&D: Essential for basic research and preclinical studies focused on the central nervous system and endogenous pain control.

Basic Information

Product Name	Enkephalin-Met, Trp(4)-
CAS No.	63074-20-4
Molecular Formula	C34H44N8O7S
Molecular Weight	708.83 g/mol
Synonyms	[Met5, Trp4]-Enkephalin; H-Tyr-Gly-Gly-Trp-Met-OH; (4-Tryptophan, 5-methionine)-Enkephalin; Methionine Enkephalin, Trp(4)-; Opioid Peptide Analog; YGGWM; Tyr-Gly-Gly-Trp-Met; δ-Selective Enkephalin Analog
EINECS	Contact for details

Quality Control

Our Enkephalin-Met, Trp(4)- is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous quality testing protocols, and specifications can be aligned with research-grade or cGMP standards upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and maintenance under inert atmosphere to ensure stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.