Description

Z-Tyr-Phe-Oh is a protected dipeptide derivative, specifically the Z-protected form of the tyrosine-phenylalanine dipeptide with a free carboxylic acid terminus. This compound serves as a crucial building block (synthon) in solid-phase and solution-phase peptide synthesis, offering precise control over the peptide chain assembly. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in developing novel therapeutic peptides and biochemical probes.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of longer, biologically active peptide sequences for drug discovery and development.
• Biochemical Research: Used as a standard or reagent in studies of enzyme kinetics, substrate specificity, and peptide-protein interactions.
• Peptide Library Construction: Essential component in the combinatorial synthesis of peptide libraries for high-throughput screening against various biological targets.
• Custom Peptide Synthesis: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides for clients.
• Protecting Group Chemistry: Serves as a practical example and tool in organic chemistry for teaching and demonstrating carboxybenzyl (Z) group protection/deprotection strategies.

Basic Information

Item	Detail
Product Name	Z-Tyr-Phe-Oh
CAS No.	63023-95-0
Molecular Formula	C26H26N2O6
Molecular Weight	462.50 g/mol
Synonyms	N-Carboxybenzyl-L-tyrosyl-L-phenylalanine; Z-L-Tyrosyl-L-phenylalanine; Z-Tyr-Phe; CBZ-L-Tyrosyl-L-phenylalanine; Nα-(Benzyloxycarbonyl)-L-tyrosyl-L-phenylalanine; (2S)-2-[[(2S)-2-(Benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoic acid; Z-Y-F-OH; N-CBZ-L-Tyrosine-L-Phenylalanine
EINECS	Contact for details

Quality Control

Our Z-Tyr-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.