Description

L-Histidine, 1-(2,4-Dinitrophenyl)-n-[(Phenylmethoxy)Carbonyl]- is a chemically modified derivative of the essential amino acid L-Histidine, featuring a dinitrophenyl (DNP) protecting group and a carboxybenzyl (Cbz) protecting group on the side chain. This compound is of significant value in advanced peptide synthesis and biochemical research, where it serves as a key protected intermediate for constructing complex peptides and studying enzyme-substrate interactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, diagnostic tools, and specialized biochemical probes.

Application

• Protected Amino Acid Intermediate in solid-phase and solution-phase peptide synthesis.
• Biochemical Research Reagent for studying histidine-related enzymatic processes and protein modifications.
• Pharmaceutical Development as a building block for novel peptide-based drug candidates.
• Production of Specialty Fine Chemicals and advanced chiral compounds.
• Academic Research in organic chemistry and bio-conjugation techniques.
• Reference Standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	L-Histidine, 1-(2,4-Dinitrophenyl)-n-[(Phenylmethoxy)Carbonyl]-
CAS No.	63013-46-7
Molecular Formula	C20H19N5O7
Molecular Weight	441.40 g/mol
Synonyms	N(alpha)-[(Phenylmethoxy)carbonyl]-N(pi)-[2,4-dinitrophenyl]-L-histidine; N(alpha)-Cbz-N(pi)-DNP-L-histidine; Cbz-His(DNP)-OH; Z-His(DNP)-OH; N(alpha)-Carbobenzoxy-N(pi)-2,4-dinitrophenyl-L-histidine; 1-(2,4-Dinitrophenyl)-N-[(benzyloxy)carbonyl]-L-histidine; L-Histidine, N2-[(phenylmethoxy)carbonyl]-N1-(2,4-dinitrophenyl)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific test results are available upon request. We adhere to a cGMP-compliant quality management system suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.