Description

2-[(2-Fluoro-Phenylamino)-Methylene]-Malonic Acid Diethyl Ester is a specialized fluorinated malonic acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its reactive methylene group and the fluorine-substituted aniline moiety, enabling precise molecular construction. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing novel herbicides and pesticides with enhanced activity and selectivity.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials with specific electronic properties.
• Chemical Research & Development: Versatile reagent for constructing complex molecular architectures in academic and industrial R&D settings.
• Fluorine Chemistry: Essential for studying structure-activity relationships (SAR) in medicinal chemistry due to the strategic fluorine atom.

Basic Information

Product Name	2-[(2-Fluoro-Phenylamino)-Methylene]-Malonic Acid Diethyl Ester
CAS No.	63010-68-4
Molecular Formula	C₁₄H₁₆FNO₄
Molecular Weight	281.28 g/mol
Synonyms	Diethyl 2-[(2-fluorophenylamino)methylene]malonate; Ethyl (2-fluorophenylamino)methylene malonate; 2-Fluoro-N-(2,2-diethoxy-2-oxoethylidene)aniline; Propanedioic acid, [(2-fluorophenylamino)methylene]-, diethyl ester; (2-Fluoroanilino)methylene malonic acid diethyl ester; 2-[(2-Fluoroanilino)methylene]malonic Acid Diethyl Ester; 63010-68-4; Diethyl (2-fluoroanilino)methylene malonate
EINECS	Contact for details

Quality Control

Our 2-[(2-Fluoro-Phenylamino)-Methylene]-Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.