Description

2-Amino-5-Chloro-3-Nitrobenzotrifluoride is a high-purity, multi-functional aromatic intermediate featuring a trifluoromethyl group, a nitro group, and an amino group, making it a versatile building block for complex synthesis. This compound is valued for its ability to introduce both electron-withdrawing and electron-donating substituents into target molecules, enabling precise tuning of physical and chemical properties. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a core structure for producing high-performance, light-fast azo dyes and organic pigments.
• Liquid Crystal & OLED Materials: Acts as a building block for electron-transport materials and charge-generating compounds in electronic displays and devices.
• Polymer Modification: Incorporated into polymer chains to impart specific properties like hydrophobicity, chemical resistance, or altered refractive index.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) to create complex biaryl structures.

Basic Information

Product Name	2-Amino-5-Chloro-3-Nitrobenzotrifluoride
CAS No.	62924-50-9
Molecular Formula	C7H4ClF3N2O2
Molecular Weight	240.57 g/mol
Synonyms	2-Amino-5-chloro-3-nitro-α,α,α-trifluorotoluene; 5-Chloro-2-nitro-α,α,α-trifluoro-m-toluidine; 2-Amino-5-chloro-α,α,α-trifluoro-3-nitrotoluene; 1-Amino-4-chloro-2-nitro-6-(trifluoromethyl)benzene; 3-Nitro-5-chloro-2-aminobenzotrifluoride; 2-Amino-5-chloro-3-nitrobenzotrifluoride; 5-Chloro-3-nitro-2-aminobenzotrifluoride; Benzenamine, 4-chloro-2-nitro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-3-Nitrobenzotrifluoride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.