Description

8-Chloro-5-Ethoxy-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One is a high-purity benzodiazepine derivative, a critical intermediate in advanced pharmaceutical synthesis. This compound matters for its role in the research and development of novel therapeutic agents, offering a reliable building block for medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on developing new active pharmaceutical ingredients (APIs) and studying structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized chemical entities.
• Biochemical Research: Investigated for its potential interactions with central nervous system receptors in preclinical studies.

Basic Information

Product Name	8-Chloro-5-Ethoxy-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One
CAS No.	62903-63-3
Molecular Formula	C₁₂H₁₃ClN₂O₂
Molecular Weight	252.70 g/mol
Synonyms	8-Chloro-5-ethoxy-1-methyl-1,4-benzodiazepin-2-one; 8-Chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2(1H)-one; 1-Methyl-8-chloro-5-ethoxy-1,4-benzodiazepin-2(3H)-one; 5-Ethoxy-8-chloro-1-methyl-1,4-benzodiazepin-2(3H)-one; Ethyl lorazepam intermediate; Lorazepam related compound B (Ethoxy analog)
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-Ethoxy-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.