Description

7-Chloro-5-(o-Fluorophenoxy)-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One is a high-purity benzodiazepine derivative, a crucial advanced pharmaceutical intermediate. Its value lies in its role as a key synthetic precursor for the development of novel therapeutic agents targeting the central nervous system. This compound is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new psychotropic drug candidates.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and method development in analytical laboratories.
• Preclinical Studies: Employed in the production of compounds for pharmacological screening and early-stage toxicology assessments.
• Process Chemistry: Utilized for route scouting, optimization, and scale-up studies in pilot plants for potential commercial manufacturing.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing specialized, low-volume compounds for client-specific research programs.

Basic Information

Product Name	7-Chloro-5-(o-Fluorophenoxy)-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One
CAS No.	62903-61-1
Molecular Formula	C₁₇H₁₂ClFN₂O₂
Molecular Weight	330.74 g/mol
Synonyms	7-Chloro-5-(2-fluorophenoxy)-1-methyl-1,4-benzodiazepin-2(3H)-one; 7-Chloro-5-(2-fluorophenoxy)-1-methyl-3H-1,4-benzodiazepin-2-one; 1-Methyl-7-chloro-5-(2-fluorophenoxy)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; o-Fluorophenoxy Benzodiazepine Derivative; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenoxy)-1-methyl-1,3-dihydro-; 62903-61-1; Benzodiazepine Intermediate
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(o-Fluorophenoxy)-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.