Description

7-Chloro-1-Methyl-5-(1-Trifluoromethylethoxy)-3H-1,4-Benzodiazepin-2(1H)-One is a high-purity pharmaceutical intermediate belonging to the benzodiazepine class of compounds. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) requiring specific pharmacological activity and structural complexity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the benzodiazepine core into more complex molecular architectures.

Basic Information

Product Name	7-Chloro-1-Methyl-5-(1-Trifluoromethoxy)-3H-1,4-Benzodiazepin-2(1H)-One
CAS No.	62903-57-5
Molecular Formula	C₁₄H₁₂ClF₃N₂O₂
Molecular Weight	332.71 g/mol
Synonyms	7-Chloro-1-methyl-5-(2,2,2-trifluoro-1-methylethoxy)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(1-Trifluoromethylethoxy)-7-chloro-1-methyl-3H-1,4-benzodiazepin-2(1H)-one; 7-Chloro-1-methyl-5-(α,α,α-trifluoro-p-tolyloxy)-3H-1,4-benzodiazepin-2(1H)-one (alternative structural representation); Benzodiazepine Derivative 62903-57-5; Intermediate for Trifluoromethyl-containing APIs
EINECS	Contact for details

Quality Control

Our 7-Chloro-1-Methyl-5-(1-Trifluoromethylethoxy)-3H-1,4-Benzodiazepin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.