Description

2-Chloro-5-Fluoropyrimidine is a versatile and high-value halogenated pyrimidine building block essential for modern synthetic chemistry. Its bifunctional reactivity, featuring both chlorine and fluorine substituents, makes it a critical intermediate for constructing complex molecular architectures with precision. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronic materials and liquid crystals.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling and modifying biomolecules in probe and linker synthesis.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis services and scale-up production under cGMP conditions.
• Academic & R&D Laboratories: Used extensively in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Chloro-5-Fluoropyrimidine
CAS No.	62802-42-0
Molecular Formula	C4H2ClFN2
Molecular Weight	132.52 g/mol
Synonyms	5-Fluoro-2-chloropyrimidine; 2-Chloro-5-fluoropyrimidine; 5-Fluoro-2-chloro-1,3-diazine; 2-Chloro-5-fluoro-1,3-diazine; Pyrimidine, 2-chloro-5-fluoro-; 2-Chloro-5-fluoropyrimidine (62802-42-0)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and GC-MS characterization, to support your R&D and production needs. A Certificate of Analysis (COA) is supplied with each batch, and custom purity grades (e.g., >98%, >99%) are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.