Description

(D-Ser4)-Leuprolide is a synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH). This compound is of significant interest in pharmaceutical research and development due to its modified structure, which can alter receptor binding affinity and metabolic stability compared to the parent Leuprolide molecule. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and endocrinology.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel GnRH analogs for therapeutic applications.
• Oncology Research: Investigated for potential use in hormone-dependent cancers, such as prostate and breast cancer, due to its action on the hypothalamic-pituitary-gonadal axis.
• Endocrinology Studies: Used in biochemical and pharmacological research to understand GnRH receptor interactions and signaling pathways.
• Peptide Chemistry: Employed as a building block or model compound in advanced peptide synthesis and structure-activity relationship (SAR) studies.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(D-Ser4)-Leuprolide
CAS No.	62621-13-0
Molecular Formula	C59H84N16O12
Molecular Weight	1209.4 g/mol
Synonyms	5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-D-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; Leuprolide (D-Ser4) analog; D-Ser4-Leuprorelin; GnRH agonist analog; [D-Ser(tBu)4, des-Gly10]-LHRH ethylamide; [D-Ser4]-Leuprolide; (D-Ser(tBu)4, des-Gly-NH210)-LHRH ethylamide
EINECS	Contact for details

Quality Control

Our (D-Ser4)-Leuprolide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade specifications suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.