Description

D-2-Thienylalanine is a non-proteinogenic amino acid derivative featuring a thiophene ring, which serves as a key chiral building block in organic synthesis and pharmaceutical research. Its unique structure makes it valuable for the development of novel bioactive compounds, including enzyme inhibitors and peptide mimetics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sulfur-containing heterocycles into their molecular designs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and metabolic disease research.
• Peptidomimetics & Drug Design: Used to synthesize peptide analogs where the thienyl group mimics phenylalanine, enhancing metabolic stability, lipophilicity, or receptor binding affinity.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators that utilize amino acid pathways.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate amino acid metabolism and transport mechanisms.
• Material Science: A potential monomer for creating specialized polymers or coatings with unique electronic or structural properties derived from the thiophene moiety.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective catalytic reactions to construct complex molecules.

Basic Information

Product Name	D-2-Thienylalanine
CAS No.	62561-76-6
Molecular Formula	C7H9NO2S
Molecular Weight	171.22 g/mol
Synonyms	(R)-2-Amino-3-(thiophen-2-yl)propanoic acid; D-3-(2-Thienyl)alanine; D-β-2-Thienylalanine; (R)-3-(2-Thienyl)alanine; D-2-Thienyl alanine; D-Thien-2-yl-Ala-OH; (2R)-2-Amino-3-thiophen-2-ylpropanoic acid; H-D-2-Thi-Ala-OH
EINECS	Contact for details

Quality Control

Our D-2-Thienylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with major pharmacopeial standards and can provide material tailored to meet specific customer specifications for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.