Description

Boc-D-Aspartic Acid CAS NO 62396-48-9 is a high-purity, enantiomerically pure derivative of aspartic acid, protected at the α-amino group with a tert-butoxycarbonyl (Boc) group. This protection is critical for enabling controlled, sequential synthesis in complex peptide and protein engineering projects, preventing unwanted side reactions. It is an essential chiral building block for pharmaceutical research, particularly in the development of therapeutic peptides, prodrugs, and bioactive compounds where the D-configuration imparts specific metabolic stability or biological activity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the solid-phase and solution-phase synthesis of peptide-based drugs and APIs.
• Peptide Research: Used in academic and industrial R&D for constructing peptides with D-amino acids to enhance proteolytic stability and modulate biological activity.
• Prodrug Design: Employed in creating prodrugs where the Boc-protected D-aspartic acid moiety aids in targeted delivery and controlled release.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of peptides to other biomolecules, dyes, or polymers.
• Asymmetric Synthesis: A valuable starting material for the synthesis of more complex, non-proteinogenic amino acids and fine chemicals.
• Biochemical Tool: Used in studying enzyme mechanisms and receptor-ligand interactions that involve aspartic acid residues.

Basic Information

Product Name	Boc-D-Aspartic Acid
CAS No.	62396-48-9
Molecular Formula	C9H15NO6
Molecular Weight	233.22 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)succinic acid; D-2-((tert-Butoxycarbonyl)amino)butanedioic acid; Boc-D-Asp-OH; N-Boc-D-aspartic acid; N-(tert-Butoxycarbonyl)-D-aspartic acid; (R)-2-(Boc-amino)succinic acid; Boc-D-Aspartic Acid; tert-Butyloxycarbonyl-D-aspartic acid
EINECS	Contact for details

Quality Control

Our Boc-D-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as chiral purity, chemical purity, and residual solvent content. We adhere to cGMP principles where applicable to guarantee supply consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.