Description

2,4-Dichloro-8-Methoxyquinazoline is a versatile and high-value halogenated quinazoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring reactive chlorine atoms and a methoxy group, makes it an essential building block for constructing complex heterocyclic systems. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of quinazoline-based drug candidates, including kinase inhibitors and anticancer agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Building block for creating organic electronic materials, ligands for metal complexes, and advanced polymers.
• Chemical Synthesis: Versatile scaffold for introducing the 8-methoxyquinazoline moiety into more complex molecular architectures via nucleophilic substitution reactions.
• Academic & R&D: Essential reagent for methodological studies in organic synthesis and medicinal chemistry research programs.

Basic Information

Product Name	2,4-Dichloro-8-Methoxyquinazoline
CAS No.	61948-60-5
Molecular Formula	C9H6Cl2N2O
Molecular Weight	229.06 g/mol
Synonyms	8-Methoxy-2,4-dichloroquinazoline; 2,4-Dichloro-8-methoxy-quinazoline; Quinazoline, 2,4-dichloro-8-methoxy-; 61948-60-5; 8-Methoxy-2,4-dichloro-quinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-8-Methoxyquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.