Description

Poly-L-Histidine is a synthetic, high-purity polypeptide composed of the essential amino acid L-histidine. This compound is valued for its unique biochemical properties, including its buffering capacity near physiological pH and its role as a metal chelator and catalyst. It is a critical material for researchers and manufacturers in the life sciences, particularly for applications in bioconjugation, drug delivery systems, and as a component in diagnostic assays. The product is supplied as Poly-L-Histidine CAS NO 61857-39-4 to ensure precise identification and sourcing.

Application

• As a key component in the development of drug delivery vehicles, such as polymeric micelles and nanoparticles, for targeted therapy.
• Utilized in bioconjugation chemistry for attaching peptides, proteins, or drugs to carriers due to its reactive side chains.
• Employed in diagnostic assay development, including ELISA and other immunoassays, as a coating or blocking agent.
• Serves as a model compound in biomedical research to study polypeptide behavior, enzyme mimics, and metal-protein interactions.
• Used in the formulation of biomaterials and hydrogels for tissue engineering and regenerative medicine applications.
• Acts as a chelating agent in biochemical processes and purification protocols.

Basic Information

Product Name	Poly-L-Histidine
CAS No.	61857-39-4
Molecular Formula	(C6H9N3O2)n
Molecular Weight	Variable (based on chain length 'n')
Synonyms	Polyhistidine; Poly(L-histidine); L-Histidine Homopolymer; PHis; PLH; Poly(His); Poly-L-Histidine Hydrobromide; Histidine Polymer
EINECS	Contact for details

Quality Control

Our Poly-L-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including determination of molecular weight distribution, amino acid analysis, and purity assessment via HPLC. A Certificate of Analysis (COA) detailing specific results for the requested grade is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (Amino Acid Analysis)	≥ 95.0%
Molecular Weight (Average)	1,000 - 5,000 Da (Custom ranges available)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.