Description

Proline, 1-Hydroxy-4,5,5-Trimethyl- (9Ci) is a specialized proline derivative, a non-proteinogenic amino acid analog of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a versatile chiral building block, offering unique steric and functional properties for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis, peptide mimetics, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and biological activity for therapeutic peptides.
• Asymmetric Catalysis Ligand Precursor: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators with improved efficacy and selectivity.
• Fine Chemical Synthesis: Utilized as a specialized building block for synthesizing complex natural products, flavors, and fragrances.
• Biochemical Research: Applied in studies of enzyme inhibition, substrate specificity, and as a probe for understanding biological transport mechanisms.

Basic Information

Item	Detail
Product Name	Proline, 1-Hydroxy-4,5,5-Trimethyl- (9Ci)
CAS No.	61856-89-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	1-Hydroxy-4,5,5-trimethylproline; 4,5,5-Trimethyl-1-hydroxyproline; 1-Hydroxy-4,5,5-trimethyl-2-pyrrolidinecarboxylic acid; (2S)-1-Hydroxy-4,5,5-trimethylpyrrolidine-2-carboxylic acid; Allo-1-hydroxy-4,5,5-trimethylproline; Hydroxytri-methylproline; L-1-Hydroxy-4,5,5-trimethylproline
EINECS	Contact for details

Quality Control

Our Proline, 1-Hydroxy-4,5,5-Trimethyl- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.