Description

Proline, 1-Hydroxy-5,5-Dimethyl- (9Ci) is a specialized proline derivative, a key chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of pharmaceuticals and bioactive compounds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring high stereochemical control.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and plant growth regulators that require specific stereochemistry for efficacy.
• Peptide Chemistry: Serves as a non-proteinogenic amino acid analog for modifying peptide backbones to enhance metabolic stability, bioavailability, and biological activity.
• Asymmetric Synthesis Catalyst: Acts as a precursor or ligand in the design of organocatalysts for enantioselective transformations.
• Biochemical Research: Employed in studies of enzyme mechanisms and as a tool compound in probing biological pathways involving proline metabolism.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals, flavors, and fragrances where precise chirality is essential.

Basic Information

Product Name	Proline, 1-Hydroxy-5,5-Dimethyl- (9Ci)
CAS No.	61856-88-0
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	1-Hydroxy-5,5-dimethylproline; 5,5-Dimethyl-1-hydroxyproline; 1-Hydroxydimethylproline; (2S,4R)-1-Hydroxy-5,5-dimethylpyrrolidine-2-carboxylic acid; 5,5-Dimethyl-4-hydroxyproline; Hydroxydimethylproline; L-1-Hydroxy-5,5-dimethylproline; Proline derivative 61856-88-0
EINECS	Contact for details

Quality Control

Our Proline, 1-Hydroxy-5,5-Dimethyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.