Description

7-Bromo-5-(2-Chlorophenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-1H-Benzo-1,4-Diazepine Monohydrochloride is a high-purity, synthetically derived benzodiazepine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a structurally complex and pharmacologically relevant scaffold for research and development in medicinal chemistry. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel central nervous system (CNS) active agents and other therapeutic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to explore new therapeutic pathways, particularly for CNS disorders.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Preclinical Studies: Employed in the development and testing of new chemical entities (NCEs) for pharmacological and toxicological profiling.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for chemical synthesis projects and pharmacological research.

Basic Information

Product Name	7-Bromo-5-(2-Chlorophenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-1H-Benzo-1,4-Diazepine Monohydrochloride
CAS No.	61802-93-5
Molecular Formula	C18H19BrClN2O·HCl
Molecular Weight	431.62 g/mol
Synonyms	7-Bromo-5-(2-chlorophenyl)-2,3-dihydro-2-(methoxymethyl)-1-methyl-1H-1,4-benzodiazepine hydrochloride; 7-Bromo-5-(o-chlorophenyl)-2,3-dihydro-2-(methoxymethyl)-1-methyl-1H-1,4-benzodiazepine HCl; 7-Bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepine hydrochloride; Ro 07-9749/001; Ro 07-9749; Ro 07-9749/000; A benzodiazepine derivative hydrochloride salt.
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-(2-Chlorophenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-1H-Benzo-1,4-Diazepine Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and pharmaceutical development. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.