Description

5-(1-Chlorovinyl)-2,4-Dichloropyrimidine is a halogenated pyrimidine derivative serving as a versatile and critical synthetic intermediate in advanced organic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer agents, leveraging the reactive chlorovinyl and chloropyrimidine groups for further functionalization.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the pyrimidine core is a common bioactive motif.
• Material Science Research: Serves as a precursor for the development of specialty polymers and ligands with tailored electronic or binding properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Stille) due to the presence of halogen atoms, enabling the formation of carbon-carbon bonds.
• Nucleoside Analog Development: Used in medicinal chemistry to create modified nucleoside structures for potential therapeutic applications.
• Chemical Library Synthesis: A valuable scaffold for combinatorial chemistry and high-throughput screening in drug discovery programs.

Basic Information

Product Name	5-(1-Chlorovinyl)-2,4-Dichloropyrimidine
CAS No.	61751-45-9
Molecular Formula	C6H3Cl3N2
Molecular Weight	209.46 g/mol
Synonyms	2,4-Dichloro-5-(1-chlorovinyl)pyrimidine; 5-(1-Chloroethenyl)-2,4-dichloropyrimidine; 5-Vinyl-2,4-dichloropyrimidine (chlorinated derivative); 2,4-Dichloro-5-(chlorovinyl)pyrimidine; Pyrimidine, 2,4-dichloro-5-(1-chlorovinyl)-; 5-(Chlorovinyl)-2,4-dichloropyrimidine
EINECS	Contact for details

Quality Control

Our 5-(1-Chlorovinyl)-2,4-Dichloropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.