Description

2-Pyrimidinesulfenyl Chloride (9Ci) is a specialized organosulfur reagent featuring a reactive sulfenyl chloride group attached to a pyrimidine heterocycle. This compound is a critical building block in advanced organic synthesis, enabling the efficient introduction of the pyrimidine-sulfenyl moiety into target molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the pyrimidine core is a common pharmacophore.
• Chemical Biology Probe Development: Serves as a reagent for the selective modification of cysteine residues in proteins or peptides, facilitating activity-based protein profiling (ABPP) and bioconjugation.
• Material Science Research: Employed in the synthesis of functionalized polymers or organic electronic materials that incorporate sulfur and nitrogen heterocycles.
• Cross-Coupling & Functionalization: Acts as an electrophilic coupling partner in various metal-catalyzed or metal-free reactions to construct complex molecular architectures.

Basic Information

Product Name	2-Pyrimidinesulfenyl Chloride (9Ci)
CAS No.	61686-49-5
Molecular Formula	C4H3ClN2S
Molecular Weight	146.60 g/mol
Synonyms	Pyrimidine-2-sulfenyl chloride; 2-Chlorosulfenylpyrimidine; 2-Pyrimidylsulfenyl chloride; 2-Pyrimidinethiol, chloride; NSC 406919; 2-Pyrimidinesulfenylchloride; 2-(Chlorothio)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Pyrimidinesulfenyl Chloride (9Ci) is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.