Description

(+)-Dobutamine CAS NO 61661-05-0 is a high-purity, enantiomerically pure form of the potent synthetic catecholamine and β-1 adrenergic receptor agonist. This compound is of critical importance in pharmaceutical research and development, serving as a key reference standard and active pharmaceutical ingredient (API) intermediate. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in cardiovascular drug development, pharmacological studies, and quality control testing.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of dobutamine in drug substances and finished dosage forms via HPLC, GC, or spectroscopic methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of finished dobutamine drug products, including injectable solutions.
• Cardiovascular Research: Employed in in vitro and in vivo studies to investigate β-1 adrenergic receptor activity, cardiac contractility, and hemodynamic effects.
• Metabolite and Impurity Synthesis: Utilized as a starting material for the synthesis of related compounds, metabolites, or degradation products for analytical method development and validation.
• Quality Control & Assurance: Essential for pharmaceutical QC labs to perform comparative analyses, ensuring the identity, strength, quality, and purity of commercial dobutamine batches.

Basic Information

Product Name	(+)-Dobutamine
CAS No.	61661-05-0
Molecular Formula	C18H23NO3
Molecular Weight	301.38 g/mol
Synonyms	(+)-Dobutamine; (R)-Dobutamine; (3R)-4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]benzene-1,2-diol; (R)-Dobutamine Hydrochloride (salt form); Dobutamine (R)-enantiomer; (R)-Dobutamine; (R)-Dobutamine; Levodobutamine; (R)-(-)-Dobutamine
EINECS	Contact for details

Quality Control

Our (+)-Dobutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.